Stereoselective Preparation of the Tricyclic Hexa-substituted Spirocyclopropane Core of Cyclohelminthol X
Org. Lett. ASAP.
In vitro synthesis of oryzamutaic acid H using recombinant L-lysineε-dehydrogenase from Agrobacterium tumefaciens
J. Biotech. 2024, 385 , 42-48.
Isolation of Paraphaeoketones: A Plausible Biosynthetic Explanation for Paraphaeolactones via a Benzilic Acid Rearrangement Rather than a Favorskii Rearrangement
J. Nat. Prod. 2024, 87 (4), 1159-1170.
Proposal for Structure Revision of Pinofuranoxin A through Total Syntheses of Stereoisomers
J. Nat.l Med, 2024, published online, .
"Fruiting Liquid” of Mushroom-Forming Fungi, A Novel Source of Bioactive Compounds – Fruiting-Body Inducer and HIF and Axl Inhibitors
J. Agr. Food Chem, 2023, 71, 13338-13345
HIV-1 Integrase Inhibitor, Dihydroobionin B, and the Investigation of Its Extraordinary Specific Rotation
J. Nat. Prod. 2023, 2139–2144
Pseudo-Enantiomeric Paraphaeolactones and Their Biosynthetic Derivatives from Paraphaeosphaeria sp. KT4192: A Proposition of a Favorskii Rearrangement for Their Biosynthesis
J. Nat. Prod. 2023, 86, 1832-1843.
Novel cyclopropyl compounds, cyclopropylvirgines A to G, from the fruiting bodies of Amanita virgineoides
Bull. Chem. Soc. Jpn. 2023, 96 (6), 503-509
Termination of the Chirality Confusion of Peribysins
Bull. Chem. Soc. Jpn. 2023, 96 (4), 318-320 (selected paper)
Integrasone Derivatives Isolated from Lepteutypa sp. KT4162 and Their Anti-HIV-1 Integrase Activity
J. Nat. Prod. 2023, 86(4), 1019-1024
Isolation of cyclohumulanoids from Daedaleopsis tricolor and their biosynthesis based on in silico simulations
Tetrahedron, 2022, 92, 132251.
Structural Determination, Total Synthesis, and Biological Activity of Iezoside, a Highly Potent Ca2+-ATPase Inhibitor from the Marine Cyanobacterium Leptochromothrix valpauliae
J. Am. Chem. Soc. 2022, 144 (24), 11019–11032.
Isolation, Identification, and DFT-based Conformational Analysis of Sesquikarahanadienone and its Congeners from Freshwater Dothideomycetes Neohelicascus aquaticus KT4120
Bull. Chem. Soc. Jpn. 2022, 95 (5), 833-845
BCSJ Award article
Biochemistry-Guided Prediction of the Absolute Configuration of Fungal Reduced Polyketides
Angewandte Chemie International Edition, 2021, 60, 43, 23403-23411
Cyclohumulanoid Sesquiterpenes from the Culture Broth of the Basidiomycetous Fungus Daedaleopsis tricolor
Molecules, 2021, 26 (14), 4364..
Isolation and Structural Elucidation of Novel Fusicoccan Dehydroxypericonicin A from Roussoella sp.
Biosci. Biotech. Biochem. 2021, 85(8), 1798-1801.
Ryuhi Kanehara, Ayane Hayasaka, Kota Inose,
Takeshi Okamura, Satomi Miura, Kazuaki Tanaka, and Masaru Hashimoto
Decaspirones and Palmarumycins from Phaeoseptum sp. KT4106: Chirality Reinvestigation of Palmarumycins CP4a and CP5
Tetrahedron Lett., 2021, 92, 132251
Osamu Ishibashi, Mami Nishiyama, Eunsang
Kwon, Masaru Hashimoto, Shigefumi Kuwahara, Masaru Enomoto
Semipinacol rearrangement of a bicyclo [7.2. 0] undecane framework into
a bicyclo [6.3. 0] undecane skeleton: A model study on the biosynthesis
of seiridiasteriscane A
Biosci. Biotech. Biochem. 2021, 85(7), 1621-2627
Inose, Kota; Tanaka, Shizuya; Tanaka, Kazuaki; Hashimoto, Masaru,
Cyclohelminthol CPs: Scope and Limitations of Density-functional-theory-based Structural Elucidation of Natural Products
J. Org. Chem., 2021, 86( 2), 1505-1515..
Anti-Japanese Encephalitis Virus (JEV) Activity of Triterpenes and Flavonoids from Euphorbia hirta
Philippine Journal of Science 149 (3), 603-613 2020
DFT-Supported structure determination of gymunomitr-3(15)-en-4b,9b-diol
Tetrahedron, 2020, 76(27), 131301
DFT Supported Structural Elucidations of Seiridiasteriscane A, Unique 15-nor-Asteriscane and Novel Pestalotiopsin Congeners from Seiridium sp. KT3957
Tetrahedron, 2020,76, (20), 131197
Mami Nishiyama, Wilanfranco C. Tayone, Hayato Maeda, Kazuaki Tanaka, Masaru
Hashimoto
DFT Supported Structural Revision of Seiricardines
Bull. Chem. Soc. Jpn. 2020, 93(6), 768-775.
Tetsuya Shiina, Taro Ozaki, Yusuke Matsu, Shota
Nagamine, Chengwei Liu, Masaru Hashimoto, Atsushi Minami, Hideaki Oikawa
Oxidative Ring Contraction by a Multifunctional Dioxygenase Generates the
Core Cycloocatadiene in the Biosynthesis of Fungal Dimeric Anhydride Zopfiellin
Org. Lett., 2020, 22 (5), 1997-2000.
Identification of neomacrophorins isolated from Trichoderma sp. 1212-03 as proteasome inhibitors.
Bioorg. Med. Chem. 2019, 27, 115161.
DFT calculation-assisted stereo-structural assignment of arundifungin
Chirality, 2020, 32, 17-31
DFT計算支援による天然物のNMR解析
日本核磁気共鳴学会機関誌、2019, vol10, 31-41.
An Efficient Protocol for Accurately Calculating 13C Chemical Shifts of Conformationally Flexible Natural Products: Scope, Assessment and Limitations.
J. Nat. Prod. 2019 82, 2299-2306.
.
Cyclopericodiol and Novel Chlorinated Melleins Isolated from Periconia macrospinosa KT3863
Tetrahedron, 2019, 75, 130470
Biosynthetic machinery of 6‐hydroxymellein derivatives leading to cyclohelminthols and palmaenones
ChemBioChem, accepted publication
Neomacrophorin and Premacrophorin Congeners from Trichoderma sp. 1212-03
Tetrahedron, 2019, 75, 2993-3000.
Structure-Activity Relationships of Trichothecenes against COLO201 Cells
and Cochliobolus miyabeanus: The Role of 12-Epoxide and Macrocyclic Moieties
Bioorg. Med. Chem. Lett. 2019. 29, 982-985.
Bioorg. Med. Chem. Lett. 2019. 29, 982-985.
Structure of two purple pigments, catechiopyranocyanidins A and B from the seed-coat of the small red bean, Vigna angularis
Scientific Reports 2019, 9, 1484.
Biosynthetic study of conidiation-inducing factor conidiogenone: heterologous production and cyclization mechanism of a key bifunctional diterpene synthase.
Biosci. Biotech. Biochem. 2019, 83, 192-201.
Synthesis of Chiral Nonracemic α-Difluoromethylthio Compounds with Tetrasubstituted Stereogenic Centers via a Palladium-Catalyzed Decarboxylative Asymmetric Allylic Alkylation.
Org. Lett. 2018, 20, 7044-7048.
リンゴ果実におけるマイコパラサイト現象の生物有機化学
日本農薬学会誌, 2018, 43, 101-108.
天然物構造決定におけるDFT計算の活用
有機合成化学協会誌 2018, 76, 842-850
Cyclohelminthols Y1-Y4 Metabolites Possessing Two Spirocyclopropanes in their Structure
J. Org. Chem. 2018, 83, 5688-5697
12-Deoxyroridin J and 12-Deoxyepiisororidin E from Calcarisporium arbuscular
Ｔetrahedron Letters, 2018. 59, 1992-1995.
Stereochemical Correction and Total Structure of Roridin J
Tetrahedron, 2017, 73, 5430-5435.
Cyclohelminthol X, a Hexa-substituted Spirocyclopropane from Helminthosporium velutinum yone96: Structural Elucidation, Electronic Circular Dichroism Analysis, and Biological Properties
J. Org. Chem. 2017, 82, 5574-5582.
Neomacrophorin X, a [4.4.3]Propellane-typed Meroterpenoid from Trichoderma sp. 1212-03
J. Nat. Prod. 2017, 80, 1484-1492.
Homopetasinic acid isolated from Diaporthe sp. strain 1308-05
Tetrahedron Letters, 2016, 57, 1117-1119
Isolation, Absolute Structures, and Biological Properties of Cyclohelminthols I–IV from Helminthosporium velutinum yone96
Tetrahedron, 2016, 72, 1400-1405
Homojesterones: vinylogous analogues of jesterone from Helminthosporium velutinum TS28
Tetrahedron 2016, 72, 1031-1035.
"Achaetolide-II isolated from Helminthosporium velutinum TS28"
Tetrahedron, 2015, 71(41) 7900-7905
Computation-Assisted Structural Elucidation of Epoxyroussoeone and Epoxyroussoedione Isolated from Roussoella japanensis KT1651
J. Nat. Prod., 2015, 78 (7), 1505–1510
Isolation, ECD Assisted Structural Analyses, Biosynthetic Discussions, and Biological activities of epi-Cochlioquinones D and its Derivatives
Tetrahedron, 2015, 71, 4788-4794.
リンゴ果実上におけるマイコパラサイト現象の分子機構
有機合成化学協会誌, 73 230-240 (2015)
Relative and absolute structure of phomolide C
Biosci. Biotech. Biochem. 2015, 79(7) 1067-1069.
Isotopic Differentiation Protocol, a Selective Extraction of C- and N-Terminal Ions in ESI-Ms/Ms De Novo Peptide Sequencing
Nat. Prod. Chem. Res. 2015, 3, 164.
"Lambertellin System, the mechanism for fungal replacement of Moniliniafructigena with Lambertellacorni-maris without competitive inhibition on ager media."
Bioorg. Med. Chem., 22, 2489, (2014).
「リンゴ果実におけるマイコパラサイト現象の生物有機化学的研究」
日本化学会生体機能関連部会ニュースレター、Vol. 28, No.3 (2014. 1. 23)
Neomacrophorin I, II, and III, novel drimenyl cyclohexanes with hydroxylated butanoates from Trichoderma sp. 1212-03
Tetrahedron, 70, 1458-1463 (2014).
Isolation and structure elucidation of potential anti-dengue metabolites from tawa-tawa (Euphorbia hirta Linn.)
Walailak Journal of Science and Technology , 2014, 11, 825-832..
「PlipastatinとFengucinにおける構造混乱の終結」
化学と生物、51, 840-843 (2013).
7-β- and 10-β-Hydroxylated congeners of CAF-603; elucidation of absolute configuration of CAF-603 family, and their SAR studies in the anti-fungal activity
Tetrahedon 2013, 69, 9469-9474 (2013).
Spartanの化学シフト計算による天然物の構造決定
Wavefunction User Letter No4.(右クリックで保存してから開くことができます。）
Roussoellols A and B, Tetracyclic Fusicoccanes from Roussoella hysterioides
J. Nat. Prod., 76, 1047–1051 (2013).
Methyl 3-iso-cucurbate, a potential bolting inhibitor to Brassica rapa
Tetrahedron 69, 5426–5430, (2013).
Structural corrections of photinides A, B and their novel derivatives
Tetrahedron, 68, 7991-7996 (2012).
Termination of the structural confusion between plipastatin A1 and fengycin IX
Bioorg. Med. Chem., 20, 3793-3798 (2012).
"Absolute Stereochemistry of Altersolanol A and Alterporriols"
Chirality, 24, 137–146 (2012).
"A novel bisretinoid of retina is an Adduct on Glycerophosphoetanolamine"
Investigative Ophthalmology & Visual Science, 51, 9084-9090 (2011).
"Absolute Stereochemistry of Novel Isochromanone Derivatives from Leptosphaeria sp. KTC 727"
Biosci. Biotech. Biochem, 75, 2390-2393 (2011).
"Syntheses of cellotriose and cellotetraose analogues as transition state mimics for mechanistic studies of cellulases"
Bioorg. Med. Chem, 19, 3812–3830 (2011).
"Stereochemical differentiation in the Simmons-Smith reaction for cyclopropanated glucopyranose derivatives as molecular probes for glycosidases"
Biosci. Biotech. Biochem, 2011, 75, 1380-1382.
Zaharenko, A.; Picolo, G.; Ferreira, W.; Murakami, T.; Kazuma, K.; Hashimoto, M.; Cury, Y.; de Freitas, J.; Konno, K
"Bunodosine 391: a new analgesic acylamino acid from the venom of the sea
anemone Bunodosoma cangicum"
J. Nat. Products, 74, 378–382 (2011).
Wilanfranco T. C.; Honma, M.; Kanamaru S.; Noguchi, S.; Tanaka, K.; Nehira,
T.; Hashimoto, M..
"Stereochemical investigations of isochromenone and isobenzofuranone isolated
from Leptosphaeria sp. KTC 727"
J. Nat. Products, 74, 425–429 (2011).
"Synthesis of a trigalacturonic acid analogue mimicking the expected transition state in the glycosidases"
Crabohydr. Res. 345, 572-585, (2010).
"Novel Neofusapyrones Isolated from Verticillium dahliae as Potent Antifungal Substances"
Bioorg. Med. Chem. Lett., 20, 709-712 (2010).
Wilanfranco T. C.; Shindo, S.; Murakami, T.; Hashimoto, M.; Tanaka, K.; Takada, N.
"Absolute stereochemistry and conformational analysis of achaetolide isolated
from Ophiobolus sp."
Tetrahedron, 65, 7464-7467 (2009).
"Biosynthetic studies of spiroleptosphol"
Bioorg. Med. Chem. Lett., 19, 1122-1125 (2009).
"Four Analogues of Spiroleptosphol isolated from Leptosphaeria doliolum"
Bioorg. Med. Chem. 19, 492-495 (2009).
"Isolation and absolute stereochemistry of optically active sydonic acid from from Glonium sp. (Hysteriales, Ascomycota)"
Biosci. Biotech. Biochem, 73, 203-204 (2009).
Structure and Biosynthesis of Norneolambertellin Produced by Lambertella sp.1346.
Bioorg. Med. Chem, Lett, 18, 16, 4547-4549 (2008).
"Spartan Essentialを導入して ～演習講義「コンピュータ分子設計学」への展開～"
日本化学会情報化学部会誌 26, 106-112 (2008)
"Spiroleptosphol isolated from Leptosphaeria doliolum"
Bioorg. Med. Chem, Lett, 18, 14, 4228-4231 (2008).
"Syntheses of Lambertellols and Their Stable Analogues; Investigation of the Real Active Species in the Mycoparasitism by Lambertella Speciese"
J. Org. Chem, 73, 5039-5047 (2008.)
"Synthesis of D-trigalacturonic acid methylglycoside"
Biosci. Biotech. Biochem, 71, 1230-1235 (2008)
"Rdc-enhanced NMR spectroscopy in structure elucidation of natural products/small molecules: Sucro-neolambertellin as a testcase"
Angew. Chem. Int. Ed. 47, 2032-2034 (2008).
"Stimulation of the Biosynthesis of the Antibiotics Lambertellols by the Mycoparasitic Fungus Lambertella corni-maris under the Acidic Conditions Produced by Its Host Fungus in Vitro",
Biosci. Biotech. Biochem., 71, 1230-1235 (2007)
An RNA polymerase inhibitor, cyclothiazomycin B1, and its isomer.
Bioorg. Med. Chem,, 14, 8259–8270 (2006)
ピラノース環酸素を硫黄原子で置換したチオオリゴサッカリドの合成研究, (総合論文)
有機合成化学協会誌, 64(7), 766-777, (2006).
Design, synthesis, and enzymatic property of a sulfur-substituted analogueof trigalacturonic acid
Bioorg. Med. Chem, Lett., 15, 22, 4932-4935 (2005).
Isolation, structure elucidation, preparation,and biological properties of neolambertellin
Bioorg. Med. Chem, Lett., 15, 4185-4188 (2005)
Synthetic studies on oligosaccharides composed of 5-thioglucopyranose units
Bioorg. Med. Chem., 13, 5113-5144 (2005)
Lambertellol C, a labile and novel biosynthetic congener of lambertellols A and B
Bioorg. Med. Chem. Lett., 15, 2587-2590 (2005).
Optimization of isotope-labeling conditions for lambertellin based on isotope patterns observed by mass spectrometry
Bioorg. Med. Chem. Lett., 15, 2591-2594 (2005).
Pachyelasides A-D, Novel Molluscicidal Triterpene Saponins from Pachyelasma Tessmannii
J. Agric. Food Chem., 53, 608-613 (2005).
Biosynthesis of Lambertellols Based on the High Specific Incorporation of the 13C-Labeled Acetates and Their Biological Properties,
J, Am. Chem. Soc., 126, 9214-9220 (2004).
Synthesis of thiosaccharides employing the Pummerer rearrangement of tetrahydrothiopyran oxides,
Tetrahedron, 60, 6829-6851 (2004).
Lambertellols A and B, Novel 3,4-Dihydronaphthalen-1(2H)-ones with Spiro-butenolide Produced by Lambertella sp.1346.
Org. Lett. 6, 157-160 (2004).
Pummerer rearrangement of 1-deoxy-5-thioglucopyranose oxides; novel synthesis of 5-thioglucopyranose derivatives.
Tetrahedron Lett., 44, 4089-4093 (2003).
α-Selective Glycosylation with 5-thioglucopyranosyl Donnors; Synthesis of an Isomaltotetraoside mimic Composed of 5-thioglucopyranose Units.
Bioorg. Med. Chem. Lett., 13, 1063-1066 (2003).
S. Synthetic studies of carzinophilin. Part 4: Chemical and biological properties of carzinophilin analogues.
Tetrahedron 59, 3089-3097 (2003).
Synthetic studies of carzinophilin. Part 3: Synthetic approach toward carzinophilin and successful synthesis of 13-O-desacetyl-12,13-di-O-benzyl-4-O-methylcarzinophilin.
Tetrahedron 59, 3063-3087 (2003).
Synthetic studies of carzinophilin. Part 2: Synthesis of 3,4-dibenzyloxy-2-methylidene-1-azabicyclo[3.1.0]hexane systems corresponding to the C1-17 fragment of carzinophilin.
Tetrahedron 59, 3041-3062 (2003).
Synthetic studies of carzinophilin. Part 1: Synthesis of 2-methylidene-1-azabicyclo[3.1.0]hexane systems related to carzinophilin.
Tetrahedron 59, 3019-3040 (2003).
β-Selective Glycosylation of 5-Thioglucopyranose Derivatives: Synthesis of β-(1-6)Linked 5'-Thioglucopyranosyl Disaccharides.
Chemistry Lett. 2002, 626-627 (2002).
Novel Preparation of (2-Azidomethyl)benzoic Acid and an Application as a Protective Group.
Syn. Commun. 32, 3347-355 (2002).
Total Synthesis of Both Enantiomers of Dictyochromenol and their (Z)-Isomers.
Biosci. Biotech. Biochem. 66, 1915-1924 (2002).
Fluorescent Pigments if the Retinal Pigment Epithelium and Age-related Macular Degeneration.
Bioorg. Med. Chem. Lett. 11, 1533-1540 (2001).
Design and Synthesis of a novel Photoaffinity Taxoid as a Potential Probe for the Study of Paclitaxel-microtubules Interactions.
Tetrahedron Lett., 41, 4287-4290 (2000).
A2E, a Lipofuscin Fluorophore, in Human Retinal Pigmented Epithelial Cells in Culture.
IVOS 40, 2988-2995 (1999).
Enantioselective Binding of an 11-cis-Locked Cyclopropyl Retinal. The Conformation of Retinal in Bovine Rhodopsin.
Org. Lett. 1, 51-54 (1999).
One Step and Convenient Preparations of 4-Hydroxyretinal and 4-Oxoretinal.
Syn. Commun. 29, 3793-3797 (1999).
Preparation and Biological Properties of Biotinylated PhTX Derivatives.
Bioorg. Med. Chem. 7, 1181-1194 (1999).
A Stereoselective Synthesis of 4-O-methyl-13-Desacetyl-12,13-di-O-benzylcarzinophilin.
Heterocycles 47, 59-64 (1998).
A Bifunctional Photoaffinity Probe for Ligand/Receptor Interaction Studies.
J, Am. Chem. Soc., 120, 8543–8544 (1998).
Isolation and One-step Preparation of A2E and Iso-A2E, Fluorophores from Human Retinal Epithelium.
Proc. Nat. Acd. Sci. USA, 95, 14609-14613 (1998).
Total Synthesis of an Enantiomeric Pair of Fr900482. 2. Synthesis of the Aromatic and Optically Active Aliphatic Segments.
Tetrahedron 53, 10239-10252 (1997).
Total Synthesis of Natural (+)-FR-900482. 2. Efficient Synthesis of the Aromatic and Optically Active Aliphatic Fragments.
Tetrahedron Lett., 37, 3475-3478 (1996).
One-step Synthesis of (5)-Epi-Hydantocidin.
Heterocycles 42, 503-508 (1996).
Novel Synthesis of (+)-Hydantocidin Based on the Plausible Biosynthetic Pathway.
Tetrahedron 52, 1177-1194 (1996).
Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 2. Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine.
Tetrahedron 50, 3905-3194 (1994).
Synthetic Studies on the Key Component of the New Generation of Quinolonecarboxylic Acid, DU-6859. 1. Synthesis of (1R,2S)-2-Fluorocyclopropylamine by the Use of Optical Resolution.
Tetrahedron 50, 3889-3904 (1994).
A Novel Synthesis of the C1-C17 Fragment of Carzinophilin.
Tetrahedron Lett., 35, 9409-9412 (1994).
A Stereoselective Synthesis of a Novel Model Compound of Carzinophilin Carrying the C6-C13 Unit with Correct Stereochemistry.
Chemistry Lett., 1101-1104 (1994).
Synthesis, Chemical Reactivity, and Cytotoxicity of Carzinophilin Congeners Carrying a 2-(Acylamino-1-alkoxycarbonyl)methylidene-1-azabicyclo[3.1.0]hexane System.
Tetrahedron Lett., 35, 2207-2210 (1994).
Asymmetric Synthesis of (1R,2S)-2-Fluorocyclopropylamine. the Key Intermediate of the New Generation of quinolonecarboxylic acid, DU-6859.
Tetrahedron Lett., 33, 3487-3490 (1992).
Synthesis and Optical Resolution of dl-cis-2-Fluorocyclopropylamine, the Key Component of the New Generation of Quinolonecarboxylic acid, DU-6859.
Tetrahedron Lett., 34, 3483-3486 (1992).
Chemical Reactivity, and Cytotoxicity of 2-Bis(alkoxycarbonyl)methylidene-1-azabicyclo[3.1.0]hexane Systems Related to Antitumor Antibiotic Carzinophilin A.
Chemistry Lett., 975-978 (1992).
Total Synthesis of the meso-Triterpene Polyether Teurilene.
J. Org. Chem. 56, 2299-2311 (1991).
Total Synthesis of (+)-Thyrsiferol, (+)-Thyrsiferyl 23-Acetate, and Teurilene.
J. Org. Chem. 55, 5088-5017 (1990).
The Absolute Configuration of 4,6-decadiyne-1,3,8-triol Isolated from Gymnopiliun spectabilis.
Bull. Chem. Soc. Jpn. 62, 2751-2752 (1989).
Effective Deprotection of 2-(Trimethylsilylethoxy)methylated Alcohols (SEM Ethers). Synthesis of Thyrsiferyl-23 Acetate.
Tetrahedron Lett., 29, 5417-5418 (1988).
A Short Step Synthesis of Teurilene. Stereocontrolled Sequential Double Cyclization of the C30-Tetraenetetraol to the Tandem Tetrahydrofurane System.
Tetrahedron Lett., 29, 5947-5948 (1988).
Total Synthesis of meso-Triterpene Ether, Teurilene. Chemistry Lett., 645-646 (1988).
Total Synthesis of (+)-Thyrsiferol and (+)-Venustatriol.
Tetrahedron Lett., 29, 1143-1144 (1988).
Synthesis of A-B-C-ring Segment of Thyrsiferol: Construction of a Strained Tetrahydropyrane Ring Existing as a Boat Form.
Tetrahedron Lett., 28, 5665-5668 (1987).